Research ArticleRheumatoid Arthritis

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

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Science Translational Medicine  20 May 2015:
Vol. 7, Issue 288, pp. 288ra76
DOI: 10.1126/scitranslmed.aaa4616

Article Information

vol. 7 no. 288 288ra76

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 10, 2014
  • Accepted for publication March 27, 2015
  • .

Author Information

  1. Karen M. Doody1,
  2. Stephanie M. Stanford1,
  3. Cristiano Sacchetti1,
  4. Mattias N. D. Svensson1,
  5. Charlotte H. Coles2,*,
  6. Nikolaos Mitakidis2,
  7. William B. Kiosses3,
  8. Beatrix Bartok4,
  9. Camille Fos1,
  10. Esther Cory5,
  11. Robert L. Sah5,
  12. Ru Liu-Bryan4,6,
  13. David L. Boyle4,
  14. Heather A. Arnett7,
  15. Tomas Mustelin8,
  16. Maripat Corr4,
  17. Jeffrey D. Esko9,
  18. Michel L. Tremblay10,11,12,
  19. Gary S. Firestein4,
  20. A. Radu Aricescu2 and
  21. Nunzio Bottini1,
  1. 1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
  2. 2Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  3. 3Core Microscopy, Scripps Research Institute, La Jolla, CA 92037, USA.
  4. 4Division of Rheumatology, Allergy and Immunology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.
  5. 5Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
  6. 6Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, San Diego, CA 92161, USA.
  7. 7Inflammation Research, Amgen Washington, Seattle, WA 98119, USA.
  8. 8Research, MedImmune, AstraZeneca, One Medimmune Way, Gaithersburg, MD 20878, USA.
  9. 9Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA.
  10. 10Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada.
  11. 11Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
  12. 12Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec H3A 1A3, Canada.
  1. Corresponding author. E-mail: nunzio{at}lji.org
  • * Present address: Laboratory for Axon Growth and Regeneration, German Centre for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.

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