20 May 2015
Vol 7, Issue 288

About The Cover

Cover image expansion

ONLINE COVER Switching Off Rheumatoid Arthritis. Safranin O–stained ankle section from a mouse on day 14 of arthritis. In another effort to protect human health, Doody et al. report that targeting the R2A protein tyrosine phosphatase RPTPσ flips the proteoglycan switch on fibroblast-like synoviocytes, decreasing arthritis severity in a mouse model. [CREDIT: KAREN DOODY AND CRISTIANO SACCHETI/LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY]