Contents
Vol 7, Issue 288
Contents
Editorial
- New blood: Creative funding of disease-specific research
A simple funding process attracts proven scientists who have never worked on asthma to study disease mechanisms and advance new targets for therapy.
Focus
- One integrin to rule them all?
Myofibroblast-derived αvβ1 integrin has emerged as a critical mediator of transforming growth factor–β activation in experimental fibrosis models.
Research Articles
- Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections
A new series of spectinomycin analogs with potency against drug-resistant bacterial pathogens was designed and developed with a structure-based approach and validated in vitro and in vivo.
- Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy
Targeting joint-lining fibroblast-like synoviocytes reduces the severity of arthritis.
- The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
The cytoplasmic prolyl-tRNA synthetase of Plasmodium falciparum is a dual-stage therapeutic target for drug development.
- Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma
Marrow-infiltrating lymphocytes (MILs) may be used as adoptive cell therapy for multiple myeloma.
- The αvβ1 integrin plays a critical in vivo role in tissue fibrosis
An αvβ1 inhibitor attenuated pulmonary and liver fibrosis in mouse models.
- Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model
Prolonged exposure to therapeutic doses of acetaminophen reduces testosterone production by human fetal testis xenografts in mice.
Editors' Choice
- Unexpected innate immunity targets for cancer
Blocking the innate immune receptor TLR2 shows promise for treating head and neck cancer.
- The bitter price of sweetness
A study in human subjects links the obesogenic effects of fructose with hunger and appetite regulation in the brain.
- Scratching the surface: Alterations of skin microbiota in the initiation of eczematous dermatitis
Naturally occurring S. aureus and C. bovis drive inflammation and immune deviation in murine eczematous dermatitis.
- More than just a fruit: Grapefruit-derived nanovectors deliver cancer drugs
Grapefruit-derived nanoparticles coated with active leukocyte plasma membrane can target tumors and effectively deliver anticancer therapeutics.
