Contents
Vol 7, Issue 287
Contents
Focus
- How to know when physicians are ready for genomic medicine
Despite perceptions to the contrary, physicians are as prepared for genomic medicine as they are for other medical innovations.
- William Heberden and reverse translation
Eighteenth-century physician-scientist William Heberden transformed science, medicine, and society in ways that remain relevant today.
Research Articles
- Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury
Serum miRNAs can predict long-term radiation-induced hematopoietic injury immediately after radiation and thereby facilitate timely medical intervention and improve overall survival of exposed individuals.
- Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies
Anti-CD20/CD3 T cell–dependent bispecific antibodies may be useful for the treatment of B cell malignancies.
- A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set
Five publicly available gene expression cohorts comparing SIRS/trauma to sepsis were split into time-matched subcohorts and summarized via multicohort analysis, which yielded an 11-gene set that was validated for discriminating patients with sepsis or infection in 15 independent cohorts.
- The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors
Finding that nicotinic receptors containing the α6 subunit, but not the α4, inhibit chronic pain points to a new set of potential therapeutic drugs.
- Classic reaction kinetics can explain complex patterns of antibiotic action
Chemical reaction kinetics explain three different effects of drug-mediated bacterial killing.
- Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis
CCR6+ myelin-reactive T cells from patients with multiple sclerosis secrete inflammatory cytokines compared to T cells from healthy subjects, showing a distinct pathogenic gene expression profile and sharing a transcriptome homology with encephalitogenic CD4+ T cells isolated from mice with experimental autoimmune encephalitis.
Editors' Choice
- Stimulated sight
Electrical stimulation of retinal neurons using photovoltaics restores sight in rats with retinal degradation.
- Malaria gives mosquitoes the munchies
The malaria parasite Plasmodium falciparum synthesizes the same chemical signals that attract the mosquito vector to nectar-producing plants.
- It takes two to tango
An engineered IL-2 fusion protein collaborates with T cell therapy to induce a multifaceted immune response in mouse tumor models.
- Night and day: Circadian rhythms and glucose tolerance
Sleep/wake cycles and timing of meals affect glucose tolerance, emphasizing the intricate homeostatic mechanisms behind glucose control.
- More precision in lung cancer therapy
New drugs specifically targeting EGFR-sensitizing mutations and the EGFR T790M resistance mutation are associated with clinical benefit in lung cancer patients with acquired EGFR T790M mutations.
Errata
