Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

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Science Translational Medicine  06 May 2015:
Vol. 7, Issue 286, pp. 286re5
DOI: 10.1126/scitranslmed.aaa2373

Setting a TRAP for the malaria parasite

Previous studies have shown that T cells induced by vaccines can clear liver-stage malaria parasites, but these vaccines have not been effective in field trials. In a new study, Bejon et al. randomly allocated 121 healthy adult male volunteers to receive either a T cell–inducing vaccine or rabies vaccine as a control. They gave antimalarials to clear malaria parasites from the subjects’ blood and then did frequent blood tests to identify new infections with the malaria parasite Plasmodium falciparum. They found that the volunteers receiving the T cell vaccine had a 67% reduction in the risk of malaria infection during 8 weeks of follow-up.

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