Research ArticleBiliary Atresia
Identification of a plant isoflavonoid that causes biliary atresia
- Kristin Lorent1,*,
- Weilong Gong1,*,
- Kyung A. Koo2,*,
- Orith Waisbourd-Zinman3,4,
- Sara Karjoo3,
- Xiao Zhao1,
- Ian Sealy5,
- Ross N. Kettleborough5,
- Derek L. Stemple5,
- Peter A. Windsor6,
- Stephen J. Whittaker7,
- John R. Porter2,
- Rebecca G. Wells1,8,† and
- Michael Pack1,9,†
- 1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
- 3Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 4Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
- 5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
- 6Faculty of Veterinary Science, University of Sydney, Camden, New South Wales 2570, Australia.
- 7Hume Livestock Health and Pest Authority, Albury, New South Wales 2640, Australia.
- 8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 9Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵†Corresponding author. E-mail: rgwells{at}mail.med.upenn.edu (R.G.W.); mpack{at}mail.med.upenn.edu (M.P.)
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↵* These authors contributed equally to this work.
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Science Translational Medicine 06 May 2015:
Vol. 7, Issue 286, pp. 286ra67
DOI: 10.1126/scitranslmed.aaa1652
Vol. 7, Issue 286, pp. 286ra67
DOI: 10.1126/scitranslmed.aaa1652
Kristin Lorent
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Weilong Gong
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kyung A. Koo
2Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Orith Waisbourd-Zinman
3Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
4Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Sara Karjoo
3Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Xiao Zhao
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ian Sealy
5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Ross N. Kettleborough
5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Derek L. Stemple
5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Peter A. Windsor
6Faculty of Veterinary Science, University of Sydney, Camden, New South Wales 2570, Australia.
Stephen J. Whittaker
7Hume Livestock Health and Pest Authority, Albury, New South Wales 2640, Australia.
John R. Porter
2Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Rebecca G. Wells
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael Pack
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
9Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
