Contents
Vol 7, Issue 286
Contents
Perspectives
- Immunology of protection from Ebola virus infection
Immunological data could be used to demonstrate Ebola vaccine efficacy.
- How to handle an industry in disruption: Intervene or laissez-faire?
The best way to mitigate disruption of the pharmaceutical industry is to sponsor initiatives that keep scientists engaged.
Research Articles
- Dysregulation of astrocyte extracellular signaling in Costello syndrome
Excessive HRAS signaling in Costello syndrome accelerates Ras-specific astroglial development and extracellular matrix accumulation, resulting in premature cortical circuit maturation.
- Identification of a plant isoflavonoid that causes biliary atresia
A plant toxin with a previously uncharacterized chemical structure causes biliary atresia in zebrafish and mammals.
- Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak
Enterococcus faecalis depletes intestinal collagen, activates the host tissue protease MMP9, and contributes to anastomotic leak.
Reports
- Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope
Loa loa microfilariae load in blood can be automatically quantified at the point of care using a mobile phone video microscope.
- Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults
Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding the malaria sequence ME-TRAP conferred 67% protection against infection with Plasmodium falciparum in Kenyan adults.
Editors' Choice
- AAV and gene therapy: It’s complicated
AAV capsid preference toward cell-surface receptors determines not just its tissue specificity but also plays a key role in immune activation.
- Out of reach
A liver-specific mechanism of effector CD8+ T cell immune surveillance is inhibited by liver fibrosis.
- Basic science: Stingy support stalls innovation
A compilation of case studies suggests that the decline in investment in U.S. basic science research threatens innovation and thus the U.S. economy.
