Research ArticleImmunotherapy

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

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Science Translational Medicine  29 Apr 2015:
Vol. 7, Issue 285, pp. 285ra63
DOI: 10.1126/scitranslmed.aaa2546

Article Information

vol. 7 no. 285 285ra63

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 7, 2014
  • Accepted for publication March 20, 2015
  • .

Author Information

  1. Patrick J. Hanley1,2,3,
  2. Jan J. Melenhorst4,
  3. Sarah Nikiforow5,
  4. Phillip Scheinberg4,
  5. James W. Blaney1,
  6. Gail Demmler-Harrison6,
  7. C. Russell Cruz1,3,
  8. Sharon Lam1,2,3,
  9. Robert A. Krance1,6,7,
  10. Kathryn S. Leung1,6,
  11. Caridad A. Martinez1,6,
  12. Hao Liu1,
  13. Daniel C. Douek8,
  14. Helen E. Heslop1,6,7,
  15. Cliona M. Rooney1,2,6,7,9,
  16. Elizabeth J. Shpall10,
  17. A. John Barrett4,
  18. John R. Rodgers2 and
  19. Catherine M. Bollard1,2,3,6,7,*
  1. 1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.
  2. 2Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
  3. 3Program for Cell Enhancement and Technologies for Immunotherapy, The Sheikh Zayed Institute for Pediatric Surgical Innovation, the Center for Cancer and Immunology Research, and the Division of Blood and Marrow Transplantation, Children’s National Health System and The George Washington University, Washington, DC 20052, USA.
  4. 4Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  5. 5Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, MA 02115, USA.
  6. 6Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
  7. 7Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
  8. 8Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  9. 9Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  10. 10Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. *Corresponding author. E-mail: cbollard{at}cnmc.org

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