Research ArticleMETABOLOMICS

Urinary metabolic signatures of human adiposity

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Science Translational Medicine  29 Apr 2015:
Vol. 7, Issue 285, pp. 285ra62
DOI: 10.1126/scitranslmed.aaa5680

Urinary metabolites and adiposity

Elliott et al. examined urinary metabolites over two 24-hour time periods in a large epidemiological study of obese individuals in the United States and UK. The urinary metabolites that were associated with adiposity were related to renal function, gut microbial metabolism, energy metabolism, skeletal muscle metabolism, branched-chain amino acid metabolism, and dietary intake. The urinary excretion patterns were reproducible over time and across the U.S. and UK population cohorts. Together, the metabolites described the metabolic disturbances of adiposity and were visualized in a metabolic reaction network. The network showed unforeseen dependencies and interconnectivities of biochemical pathways that were perturbed in adiposity and pointed to the collective importance of metabolism, diet, environment, and life-style in the ongoing obesity epidemic.

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