Research ArticleCOMPUTATIONAL MODELING
Trauma in silico: Individual-specific mathematical models and virtual clinical populations
- David Brown1,
- Rami A. Namas2,
- Khalid Almahmoud2,
- Akram Zaaqoq3,
- Joydeep Sarkar1,
- Derek A. Barclay2,
- Jinling Yin2,
- Ali Ghuma2,
- Andrew Abboud2,
- Gregory Constantine4,
- Gary Nieman5,
- Ruben Zamora2,6,
- Steven C. Chang1,
- Timothy R. Billiar2 and
- Yoram Vodovotz2,6,*
- 1Immunetrics Inc., Pittsburgh, PA 15219, USA.
- 2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
- 3Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
- 4Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
- 5Department of Surgery, Upstate Medical University, Syracuse, NY 13210, USA.
- 6Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
- ↵*Corresponding author. E-mail: vodovotzy{at}upmc.edu
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Science Translational Medicine 29 Apr 2015:
Vol. 7, Issue 285, pp. 285ra61
DOI: 10.1126/scitranslmed.aaa3636
Vol. 7, Issue 285, pp. 285ra61
DOI: 10.1126/scitranslmed.aaa3636
David Brown
1Immunetrics Inc., Pittsburgh, PA 15219, USA.
Rami A. Namas
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Khalid Almahmoud
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Akram Zaaqoq
3Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Joydeep Sarkar
1Immunetrics Inc., Pittsburgh, PA 15219, USA.
Derek A. Barclay
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Jinling Yin
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ali Ghuma
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Andrew Abboud
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Gregory Constantine
4Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Gary Nieman
5Department of Surgery, Upstate Medical University, Syracuse, NY 13210, USA.
Ruben Zamora
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
6Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
Steven C. Chang
1Immunetrics Inc., Pittsburgh, PA 15219, USA.
Timothy R. Billiar
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Yoram Vodovotz
2Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
6Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
