29 April 2015
Vol 7, Issue 285
  • Contents

    • Editorial

      • Transforming training to reflect the workforce

        Twenty-first century training programs seek to provide the “BEST” graduate education for our future biomedical workforce.

    • Focus

      • American medical education at a crossroads

        New research-deficient systems of medical education could diminish the translation of biomedical advances to patients.

      • Renal denervation: Not as easy as it looks

        Renal sympathetic denervation in hypertensive patients is less effective than anticipated, owing to radio frequency energy being applied to a part of the renal artery where the nerves are at the greatest distance from the aortic lumen, and to distortion of energy distribution and temperature gradients by regional tissue anatomical variations (Tzafriri et al., this issue).

    • Research Articles

    • Editors' Choice

      • Sleep well, breathe well, age well

        Sleep-disordered breathing hastens cognitive decline by a decade, but positive airway pressure treatment may offset this effect.

      • Checkpoint inhibitors continue to check out

        Three articles are the latest clinical evidence of efficacy for anti–PD-1 antibodies as treatment for advanced melanoma and non–small cell lung cancer.

      • Childhood memory

        Epigenetic profile maturation in blood lymphocytes appears to occur during early childhood development in human females.

About The Cover

Cover image expansion

ONLINE COVER Denervation Device. This multielectrode catheter inserted into the renal artery and irrigated with saline, delivers a radiofrequency signal that ablates the renal nerve. Tzafriri et al. test this procedure's effect on hypertension in pigs, showing that local anatomy markedly affects the effectiveness of the ablation and therefore its ability to reduce blood pressure. [CREDIT: BIOSENSE WEBSTER, INC]