Contents
Vol 7, Issue 285
Contents
Editorial
- Transforming training to reflect the workforce
Twenty-first century training programs seek to provide the “BEST” graduate education for our future biomedical workforce.
Focus
- American medical education at a crossroads
New research-deficient systems of medical education could diminish the translation of biomedical advances to patients.
- Renal denervation: Not as easy as it looks
Renal sympathetic denervation in hypertensive patients is less effective than anticipated, owing to radio frequency energy being applied to a part of the renal artery where the nerves are at the greatest distance from the aortic lumen, and to distortion of energy distribution and temperature gradients by regional tissue anatomical variations (Tzafriri et al., this issue).
Research Articles
- Trauma in silico: Individual-specific mathematical models and virtual clinical populations
A mathematical model of the human response to trauma replicates individual patient outcomes but predicts unexpected results in populations.
- Urinary metabolic signatures of human adiposity
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co-metabolites, were reproducibly associated with human adiposity.
- CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo
CMV-specific T cells, derived from the naïve population, recognize different epitopes of CMV than do memory-derived T cells and may be functional and protective in vivo.
- Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients
Patient-specific, image-based design coupled with 3D biomaterial printing produced personalized implants for treatment of collapsed airways in patients with tracheobronchomalacia.
- Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension
Local tissue anatomy determines the success of renal nerve ablation and explains its variable effects on blood pressure.
Editors' Choice
- Sleep well, breathe well, age well
Sleep-disordered breathing hastens cognitive decline by a decade, but positive airway pressure treatment may offset this effect.
- Checkpoint inhibitors continue to check out
Three articles are the latest clinical evidence of efficacy for anti–PD-1 antibodies as treatment for advanced melanoma and non–small cell lung cancer.
- Behold morphing monocytes at sites of liver damage
Classical proinflammatory monocytes transition to a pro-repair phenotype during repair of sterile tissue damage in the liver.
- Childhood memory
Epigenetic profile maturation in blood lymphocytes appears to occur during early childhood development in human females.
