Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Polina L. Yarova; Alecia L. Stewart; Venkatachalem Sathish; Rodney D. Britt; Michael A. Thompson; Alexander P.  P. Lowe; Michelle Freeman; Bharathi Aravamudan; Hirohito Kita; Sarah C. Brennan; Martin Schepelmann; Thomas Davies; Sun Yung; Zakky Cholisoh; Emma J. Kidd; William R. Ford; Kenneth J. Broadley; Katja Rietdorf; Wenhan Chang; Mohd E. Bin Khayat; Donald T. Ward; Christopher J. Corrigan; Jeremy P. T. Ward; Paul J. Kemp; Christina M. Pabelick; Y. S. Prakash; Daniela Riccardi

doi:10.1126/scitranslmed.aaa0282

Research ArticleAsthma

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Polina L. Yarova¹,
Alecia L. Stewart²,*,
Venkatachalem Sathish²,*,
Rodney D. Britt Jr.²,*,
Michael A. Thompson²,*,
Alexander P. P. Lowe⁴,*,
Michelle Freeman²,
Bharathi Aravamudan²,
Hirohito Kita³,
Sarah C. Brennan¹,
Martin Schepelmann¹,
Thomas Davies¹,
Sun Yung¹,
Zakky Cholisoh⁴,
Emma J. Kidd⁴,
William R. Ford⁴,
Kenneth J. Broadley⁴,
Katja Rietdorf⁵,
Wenhan Chang⁶,
Mohd E. Bin Khayat⁷,
Donald T. Ward⁷,
Christopher J. Corrigan⁸,
Jeremy P. T. Ward⁸,
Paul J. Kemp¹,
Christina M. Pabelick²,
Y. S. Prakash²,† and
Daniela Riccardi¹,†

¹School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
²Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.
³Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
⁴Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.
⁵Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
⁶Department of Medicine, UCSF School of Medicine, San Francisco, CA 94143, USA.
⁷Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
⁸Division of Asthma, Allergy and Lung Biology, King’s College London, London SE1 9RT, UK.

↵†Corresponding author. E-mail: riccardi{at}cf.ac.uk (D.R.); prakash.ys{at}mayo.edu (Y.S.P.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 22 Apr 2015:
Vol. 7, Issue 284, pp. 284ra60
DOI: 10.1126/scitranslmed.aaa0282

Polina L. Yarova

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Alecia L. Stewart

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Venkatachalem Sathish

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Rodney D. Britt Jr.

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Michael A. Thompson

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Alexander P. P. Lowe

4Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

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Michelle Freeman

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Bharathi Aravamudan

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Hirohito Kita

3Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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Sarah C. Brennan

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Martin Schepelmann

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Thomas Davies

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Sun Yung

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Zakky Cholisoh

4Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

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Emma J. Kidd

4Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

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William R. Ford

4Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

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Kenneth J. Broadley

4Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

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Katja Rietdorf

5Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.

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Wenhan Chang

6Department of Medicine, UCSF School of Medicine, San Francisco, CA 94143, USA.

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Mohd E. Bin Khayat

7Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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Donald T. Ward

7Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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Christopher J. Corrigan

8Division of Asthma, Allergy and Lung Biology, King’s College London, London SE1 9RT, UK.

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Jeremy P. T. Ward

8Division of Asthma, Allergy and Lung Biology, King’s College London, London SE1 9RT, UK.

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Paul J. Kemp

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Christina M. Pabelick

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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Y. S. Prakash

2Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

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For correspondence: riccardi@cf.ac.uk prakash.ys@mayo.edu

Daniela Riccardi

1School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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For correspondence: riccardi@cf.ac.uk prakash.ys@mayo.edu

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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

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