Research ArticleBioengineering
An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
- Oliver Jonas1,
- Heather M. Landry1,
- Jason E. Fuller1,2,
- John T. Santini Jr.2,
- Jose Baselga3,
- Robert I. Tepper2,4,
- Michael J. Cima1,5 and
- Robert Langer1,6,*
- 1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Kibur Medical Inc., 29 Newbury Street, Suite 301, Boston, MA 02116, USA.
- 3Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 4Third Rock Ventures LLC, 29 Newbury Street, Boston, MA 02116, USA.
- 5Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 6Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵*Corresponding author. E-mail: rlanger{at}mit.edu
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Science Translational Medicine 22 Apr 2015:
Vol. 7, Issue 284, pp. 284ra57
DOI: 10.1126/scitranslmed.3010564
Vol. 7, Issue 284, pp. 284ra57
DOI: 10.1126/scitranslmed.3010564
Oliver Jonas
1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Heather M. Landry
1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jason E. Fuller
1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Kibur Medical Inc., 29 Newbury Street, Suite 301, Boston, MA 02116, USA.
John T. Santini Jr.
2Kibur Medical Inc., 29 Newbury Street, Suite 301, Boston, MA 02116, USA.
Jose Baselga
3Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Robert I. Tepper
2Kibur Medical Inc., 29 Newbury Street, Suite 301, Boston, MA 02116, USA.
4Third Rock Ventures LLC, 29 Newbury Street, Boston, MA 02116, USA.
Michael J. Cima
1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Robert Langer
1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
