22 April 2015
Vol 7, Issue 284
  • Contents

    • Focus

      • Is the third interferon a charm?

        IFNλ restores the integrity of the blood brain barrier, which is disrupted by West Nile virus infection, thereby reducing neuroinvasion and increasing survival in a mouse model of the disease.

    • Perspective

    • Research Articles

    • Reports

      • Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans

        Disseminated infection with Ureaplasma species causes fatal hyperammonemia syndrome in lung transplant recipients, likely by disrupting ammonia metabolism.

    • Editors' Choice

      • Cracking the bell jar

        Lithium and the antidepressant paroxetine inhibit GSK3β through FKBP51.

      • Seek and destroy—and discover

        Functional analysis of a patient-derived mutation unveils a new mode of regulation for the Fanconi-anemia signaling network.

      • A sticky situation helps colitis

        A liquid drug that changes to a gel when exposed to body heat shows promise as a topical treatment for inflammatory bowel disease.

About The Cover

Cover image expansion

ONLINE COVER Lab in a Tumor. Taking the lab to the patient, this week's issue features two different groups that have developed devices for testing drug sensitivity directly within the tumor. Jonas et al. (left tumor, on cover) engineered tiny, cylindrical devices with 16 wells for implantation by needle in the tumor. After a period of time in mice, the device and surrounding tissue were removed for staining. Similarly, Klinghoffer et al. (right tumor) created a microinjection device that delivered multiple drugs to tumors in mice, dogs, and humans; tumors were then removed and analyzed for response to chemotherapy. Both devices were more accurate than traditional in vitro assays and matched the systemic response in mice, suggesting that these devices could be used to better predict—and personalize—anticancer therapies. See related Perspective by Coombes. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]