Contents
Vol 7, Issue 284
Contents
Focus
- Evolution in translational science: Whither the CTSAs?
CTSA-funded institutions are naturally equipped to drive research on human phenotyping and, in turn, shape the practice of precision medicine in the clinic of the future.
- Is the third interferon a charm?
IFNλ restores the integrity of the blood brain barrier, which is disrupted by West Nile virus infection, thereby reducing neuroinvasion and increasing survival in a mouse model of the disease.
Perspective
- Drug testing in the patient: Toward personalized cancer treatment
Delivery of cancer drugs directly into tumors in vivo can indicate cancer sensitivity and predict systemic response (Jonas et al. and Klinghoffer et al., this issue).
Research Articles
- Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo
Monoclonal antibodies that inhibit human Treg function in vivo may be used therapeutically in cancer or infections.
- An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
An implantable microdevice is demonstrated to release microdoses of multiple drugs into confined regions of tumors and allows for assessment of each drug’s efficacy to identify optimal therapy.
- A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor
Simultaneous in vivo assessment of multiple cancer drugs and drug combinations using microinjection technology predicts systemic response in model tumors and has shown feasibility for assessment of drug efficacy in a pilot study in cancer patients.
- Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier
Interferon-λ signaling tightens the blood-brain barrier and limits the ability of West Nile virus to infect the central nervous system in mice.
- Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma
Calcilytics reduce airway hyperresponsiveness and inflammation and may represent effective asthma therapeutics.
Reports
- Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans
Disseminated infection with Ureaplasma species causes fatal hyperammonemia syndrome in lung transplant recipients, likely by disrupting ammonia metabolism.
Editors' Choice
- Cracking the bell jar
Lithium and the antidepressant paroxetine inhibit GSK3β through FKBP51.
- Seek and destroy—and discover
Functional analysis of a patient-derived mutation unveils a new mode of regulation for the Fanconi-anemia signaling network.
- A sticky situation helps colitis
A liquid drug that changes to a gel when exposed to body heat shows promise as a topical treatment for inflammatory bowel disease.
