22 April 2015
Vol 7, Issue 284

About The Cover

Cover image expansion

ONLINE COVER Lab in a Tumor. Taking the lab to the patient, this week's issue features two different groups that have developed devices for testing drug sensitivity directly within the tumor. Jonas et al. (left tumor, on cover) engineered tiny, cylindrical devices with 16 wells for implantation by needle in the tumor. After a period of time in mice, the device and surrounding tissue were removed for staining. Similarly, Klinghoffer et al. (right tumor) created a microinjection device that delivered multiple drugs to tumors in mice, dogs, and humans; tumors were then removed and analyzed for response to chemotherapy. Both devices were more accurate than traditional in vitro assays and matched the systemic response in mice, suggesting that these devices could be used to better predict—and personalize—anticancer therapies. See related Perspective by Coombes. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]