Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

Michaela Semeraro; Sylvie Rusakiewicz; Véronique Minard-Colin; Nicolas F. Delahaye; David Enot; Frédéric Vély; Aurélien Marabelle; Benjamin Papoular; Christelle Piperoglou; Mirco Ponzoni; Patrizia Perri; Andrei Tchirkov; Jessica Matta; Valérie Lapierre; Tala Shekarian; Sandrine Valsesia-Wittmann; Frédéric Commo; Nicole Prada; Vichnou Poirier-Colame; Brigitte Bressac; Sophie Cotteret; Laurence Brugieres; Françoise Farace; Nathalie Chaput; Guido Kroemer; Dominique Valteau-Couanet; Laurence Zitvogel

doi:10.1126/scitranslmed.aaa2327

Research ArticleCancer

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

Michaela Semeraro¹,²,³,⁴,⁵,⁶,*,
Sylvie Rusakiewicz¹,²,⁷,*,
Véronique Minard-Colin¹,²,³,
Nicolas F. Delahaye¹,²,
David Enot¹,⁵,⁶,
Frédéric Vély⁸,⁹,¹⁰,¹¹,
Aurélien Marabelle¹²,
Benjamin Papoular¹,²,
Christelle Piperoglou¹¹,
Mirco Ponzoni¹³,
Patrizia Perri¹³,
Andrei Tchirkov¹⁴,¹⁵,
Jessica Matta⁸,⁹,¹⁰,
Valérie Lapierre¹,¹⁶,
Tala Shekarian¹²,
Sandrine Valsesia-Wittmann¹²,
Frédéric Commo¹,²,
Nicole Prada¹,²,
Vichnou Poirier-Colame¹,²,
Brigitte Bressac¹⁷,
Sophie Cotteret¹,²,
Laurence Brugieres¹,³,
Françoise Farace¹,¹⁸,
Nathalie Chaput¹,²,⁷,
Guido Kroemer¹,⁵,⁶,¹⁹,²⁰,†,
Dominique Valteau-Couanet¹,²,³,‡ and
Laurence Zitvogel¹,²,⁴,⁷,†,‡

¹Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.
²INSERM U1015, GRCC, 94805 Villejuif, France.
³Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.
⁴University of Paris Sud XI, 94805 Villejuif, France.
⁵Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.
⁶INSERM U1138, 94805 Villejuif, France.
⁷Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.
⁸Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.
⁹CNRS, UMR7280, F-13009 Marseille, France.
¹⁰Aix Marseille Université, UM2, F-13009 Marseille, France.
¹¹Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.
¹²Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.
¹³Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.
¹⁴EA 4677 ERTICa, CHU et Centre Jean Perrin, 63011 Clermont-Ferrand, France.
¹⁵CHU de Clermont-Ferrand, Service de Cytogénétique Médicale, Hôpital Estaing, 63001 Clermont-Ferrand, France.
¹⁶Cell Therapy Unit, GRCC, 94805 Villejuif, France.
¹⁷Service de Génétique, Molecular Genetic Department, GRCC, 94805 Villejuif, France.
¹⁸INSERM U981, 94805 Villejuif, France.
¹⁹University of Paris Descartes/ParisV, Sorbonne Paris Cité, 75005 Paris, France.
²⁰Pôle de Biologie, Hôpital Européen Georges Pompidou, 75015 Paris, France.

↵†Corresponding author. E-mail: laurence.zitvogel{at}gustaveroussy.fr (L.Z.); kroemer{at}orange.fr (G.K.)

↵* These authors contributed equally to this work.
↵‡ These authors contributed equally to this work.

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Science Translational Medicine 15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra55
DOI: 10.1126/scitranslmed.aaa2327

Michaela Semeraro

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.University of Paris Sud XI, 94805 Villejuif, France.Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.INSERM U1138, 94805 Villejuif, France.

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Sylvie Rusakiewicz

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.

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Véronique Minard-Colin

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Nicolas F. Delahaye

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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David Enot

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Frédéric Vély

Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.CNRS, UMR7280, F-13009 Marseille, France.Aix Marseille Université, UM2, F-13009 Marseille, France.Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.

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Aurélien Marabelle

Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.

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Benjamin Papoular

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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Christelle Piperoglou

Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.

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Mirco Ponzoni

Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.

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Patrizia Perri

Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.

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Andrei Tchirkov

EA 4677 ERTICa, CHU et Centre Jean Perrin, 63011 Clermont-Ferrand, France.CHU de Clermont-Ferrand, Service de Cytogénétique Médicale, Hôpital Estaing, 63001 Clermont-Ferrand, France.

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Jessica Matta

Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.CNRS, UMR7280, F-13009 Marseille, France.Aix Marseille Université, UM2, F-13009 Marseille, France.

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Valérie Lapierre

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.Cell Therapy Unit, GRCC, 94805 Villejuif, France.

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Tala Shekarian

Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.

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Sandrine Valsesia-Wittmann

Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.

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Frédéric Commo

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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Nicole Prada

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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Vichnou Poirier-Colame

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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Brigitte Bressac

Service de Génétique, Molecular Genetic Department, GRCC, 94805 Villejuif, France.

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Sophie Cotteret

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.

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Laurence Brugieres

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.

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Françoise Farace

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U981, 94805 Villejuif, France.

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Nathalie Chaput

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Guido Kroemer

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.INSERM U1138, 94805 Villejuif, France.University of Paris Descartes/ParisV, Sorbonne Paris Cité, 75005 Paris, France.Pôle de Biologie, Hôpital Européen Georges Pompidou, 75015 Paris, France.

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For correspondence: laurence.zitvogel@gustaveroussy.fr kroemer@orange.fr

Dominique Valteau-Couanet

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Laurence Zitvogel

Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.INSERM U1015, GRCC, 94805 Villejuif, France.University of Paris Sud XI, 94805 Villejuif, France.Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.

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For correspondence: laurence.zitvogel@gustaveroussy.fr kroemer@orange.fr

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Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

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