Research ArticleCancer Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients Michaela Semeraro1,2,3,4,5,6,*, Sylvie Rusakiewicz1,2,7,*, Véronique Minard-Colin1,2,3, Nicolas F. Delahaye1,2, David Enot1,5,6, Frédéric Vély8,9,10,11, Aurélien Marabelle12, Benjamin Papoular1,2, Christelle Piperoglou11, Mirco Ponzoni13, Patrizia Perri13, Andrei Tchirkov14,15, Jessica Matta8,9,10, Valérie Lapierre1,16, Tala Shekarian12, Sandrine Valsesia-Wittmann12, Frédéric Commo1,2, Nicole Prada1,2, Vichnou Poirier-Colame1,2, Brigitte Bressac17, Sophie Cotteret1,2, Laurence Brugieres1,3, Françoise Farace1,18, Nathalie Chaput1,2,7, Guido Kroemer1,5,6,19,20,†, Dominique Valteau-Couanet1,2,3,‡ and Laurence Zitvogel1,2,4,7,†,‡1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.3Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.4University of Paris Sud XI, 94805 Villejuif, France.5Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.6INSERM U1138, 94805 Villejuif, France.7Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.8Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.9CNRS, UMR7280, F-13009 Marseille, France.10Aix Marseille Université, UM2, F-13009 Marseille, France.11Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.12Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.13Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.14EA 4677 ERTICa, CHU et Centre Jean Perrin, 63011 Clermont-Ferrand, France.15CHU de Clermont-Ferrand, Service de Cytogénétique Médicale, Hôpital Estaing, 63001 Clermont-Ferrand, France.16Cell Therapy Unit, GRCC, 94805 Villejuif, France.17Service de Génétique, Molecular Genetic Department, GRCC, 94805 Villejuif, France.18INSERM U981, 94805 Villejuif, France.19University of Paris Descartes/ParisV, Sorbonne Paris Cité, 75005 Paris, France.20Pôle de Biologie, Hôpital Européen Georges Pompidou, 75015 Paris, France.↵†Corresponding author. E-mail: laurence.zitvogel{at}gustaveroussy.fr (L.Z.); kroemer{at}orange.fr (G.K.)↵* These authors contributed equally to this work.↵‡ These authors contributed equally to this work. See allHide authors and affiliations Science Translational Medicine 15 Apr 2015:Vol. 7, Issue 283, pp. 283ra55DOI: 10.1126/scitranslmed.aaa2327 Michaela Semeraro 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.3Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.4University of Paris Sud XI, 94805 Villejuif, France.5Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.6INSERM U1138, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sylvie Rusakiewicz 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.7Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Véronique Minard-Colin 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.3Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nicolas F. Delahaye 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site David Enot 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.5Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.6INSERM U1138, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Frédéric Vély 8Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.9CNRS, UMR7280, F-13009 Marseille, France.10Aix Marseille Université, UM2, F-13009 Marseille, France.11Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aurélien Marabelle 12Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Benjamin Papoular 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christelle Piperoglou 11Service d’Immunologie, Assistance Publique–Hôpitaux de Marseille, Hôpital de la Conception, F-13009 Marseille, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mirco Ponzoni 13Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Patrizia Perri 13Giannina Gaslini Hospital, Experimental Therapy Unit Laboratory of Oncology, 16147 Genoa, Italy.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrei Tchirkov 14EA 4677 ERTICa, CHU et Centre Jean Perrin, 63011 Clermont-Ferrand, France.15CHU de Clermont-Ferrand, Service de Cytogénétique Médicale, Hôpital Estaing, 63001 Clermont-Ferrand, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jessica Matta 8Centre d’Immunologie de Marseille-Luminy, INSERM, U1104, F-13009 Marseille, France.9CNRS, UMR7280, F-13009 Marseille, France.10Aix Marseille Université, UM2, F-13009 Marseille, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Valérie Lapierre 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.16Cell Therapy Unit, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tala Shekarian 12Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sandrine Valsesia-Wittmann 12Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, 69000 Lyon, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Frédéric Commo 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nicole Prada 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Vichnou Poirier-Colame 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Brigitte Bressac 17Service de Génétique, Molecular Genetic Department, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sophie Cotteret 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Laurence Brugieres 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.3Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Françoise Farace 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.18INSERM U981, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nathalie Chaput 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.7Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Guido Kroemer 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.5Equipe 11 labelisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.6INSERM U1138, 94805 Villejuif, France.19University of Paris Descartes/ParisV, Sorbonne Paris Cité, 75005 Paris, France.20Pôle de Biologie, Hôpital Européen Georges Pompidou, 75015 Paris, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: laurence.zitvogel@gustaveroussy.fr kroemer@orange.fr Dominique Valteau-Couanet 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.3Department of Pediatric Oncology, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Laurence Zitvogel 1Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.2INSERM U1015, GRCC, 94805 Villejuif, France.4University of Paris Sud XI, 94805 Villejuif, France.7Center of Clinical Investigations in Biotherapies of Cancer, CICBT507, GRCC, 94805 Villejuif, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: laurence.zitvogel@gustaveroussy.fr kroemer@orange.fr Article Figures & Data Info & Metrics eLetters PDF eLetters is an online forum for ongoing peer review. 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Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients By Michaela Semeraro, Sylvie Rusakiewicz, Véronique Minard-Colin, Nicolas F. Delahaye, David Enot, Frédéric Vély, Aurélien Marabelle, Benjamin Papoular, Christelle Piperoglou, Mirco Ponzoni, Patrizia Perri, Andrei Tchirkov, Jessica Matta, Valérie Lapierre, Tala Shekarian, Sandrine Valsesia-Wittmann, Frédéric Commo, Nicole Prada, Vichnou Poirier-Colame, Brigitte Bressac, Sophie Cotteret, Laurence Brugieres, Françoise Farace, Nathalie Chaput, Guido Kroemer, Dominique Valteau-Couanet, Laurence Zitvogel Science Translational Medicine15 Apr 2015 : 283ra55 Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients. Supplementary Materials
Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients By Michaela Semeraro, Sylvie Rusakiewicz, Véronique Minard-Colin, Nicolas F. Delahaye, David Enot, Frédéric Vély, Aurélien Marabelle, Benjamin Papoular, Christelle Piperoglou, Mirco Ponzoni, Patrizia Perri, Andrei Tchirkov, Jessica Matta, Valérie Lapierre, Tala Shekarian, Sandrine Valsesia-Wittmann, Frédéric Commo, Nicole Prada, Vichnou Poirier-Colame, Brigitte Bressac, Sophie Cotteret, Laurence Brugieres, Françoise Farace, Nathalie Chaput, Guido Kroemer, Dominique Valteau-Couanet, Laurence Zitvogel Science Translational Medicine15 Apr 2015 : 283ra55 Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients. Supplementary Materials
