Research ArticleCancer

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

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Science Translational Medicine  15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra55
DOI: 10.1126/scitranslmed.aaa2327

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Unleashing the natural killer within

Natural killer cells, a part of the innate immune system, can kill cancer cells. Neuroblastoma is a common pediatric cancer that is difficult to treat, especially in older children with metastatic disease. The immune system helps to control the spread of neuroblastoma, and immune-based treatments for this cancer are under active investigation. Now, Semeraro et al. analyzed the role of natural killer cells in neuroblastoma and sought to understand why they are not always equally effective against the tumor. The authors found that the key lies in the predominant isoform of a receptor that natural killer cells use to interact with neuroblastoma cells and that the balance between isoforms of this receptor on a patient’s cells can help predict survival.

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