Research ArticleCancer

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

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Science Translational Medicine  15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra54
DOI: 10.1126/scitranslmed.aaa1408

Article Information

vol. 7 no. 283 283ra54

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History: 
  • Received for publication October 23, 2014
  • Accepted for publication January 27, 2015
  • .

Author Information

  1. Nicholas McGranahan1,2,*,
  2. Francesco Favero3,
  3. Elza C. de Bruin4,
  4. Nicolai Juul Birkbak1,3,4,*,
  5. Zoltan Szallasi3,5 and
  6. Charles Swanton1,4,*,
  1. 1Cancer Research UK London Research Institute, London WC2A 3LY, UK.
  2. 2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK.
  3. 3Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.
  4. 4UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.
  5. 5Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. E-mail: charles.swanton{at}crick.ac.uk
  • * Present address: Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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