Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Nicholas McGranahan; Francesco Favero; Elza C. de Bruin; Nicolai Juul Birkbak; Zoltan Szallasi; Charles Swanton

doi:10.1126/scitranslmed.aaa1408

Research ArticleCancer

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Nicholas McGranahan¹,²,*,
Francesco Favero³,
Elza C. de Bruin⁴,
Nicolai Juul Birkbak¹,³,⁴,*,
Zoltan Szallasi³,⁵ and
Charles Swanton¹,⁴,*,†

¹Cancer Research UK London Research Institute, London WC2A 3LY, UK.
²Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK.
³Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.
⁴UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.
⁵Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA 02115, USA.

↵†Corresponding author. E-mail: charles.swanton{at}crick.ac.uk

↵* Present address: Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Science Translational Medicine 15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra54
DOI: 10.1126/scitranslmed.aaa1408

Nicholas McGranahan

1Cancer Research UK London Research Institute, London WC2A 3LY, UK.

2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK.

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Francesco Favero

3Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.

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Elza C. de Bruin

4UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.

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Nicolai Juul Birkbak

1Cancer Research UK London Research Institute, London WC2A 3LY, UK.

3Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.

4UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.

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Zoltan Szallasi

3Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.

5Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA 02115, USA.

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Charles Swanton

1Cancer Research UK London Research Institute, London WC2A 3LY, UK.

4UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.

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For correspondence: charles.swanton@crick.ac.uk

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Pan-cancer analysis of tumor subclonal structures uncovers widespread intratumor heterogeneity in actionable driver events and reveals mutational processes fueling their selection.

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

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