Research ArticleCancer
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
- Nicholas McGranahan1,2,*,
- Francesco Favero3,
- Elza C. de Bruin4,
- Nicolai Juul Birkbak1,3,4,*,
- Zoltan Szallasi3,5 and
- Charles Swanton1,4,*,†
- 1Cancer Research UK London Research Institute, London WC2A 3LY, UK.
- 2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK.
- 3Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.
- 4UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.
- 5Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA 02115, USA.
- ↵†Corresponding author. E-mail: charles.swanton{at}crick.ac.uk
↵* Present address: Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.
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Science Translational Medicine 15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra54
DOI: 10.1126/scitranslmed.aaa1408
