You are currently viewing the editor's summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
Register for free to read this article
As a service to the community, this article is available for free. Existing users log in.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Uncovering a tumor’s family tree
In the era of targeted anticancer drugs, correctly identifying the mutations in a tumor becomes an essential part of optimizing cancer treatment. This is not necessarily straightforward because tumors can contain both “driver” mutations, which control tumor growth and therefore should be blocked with specific drugs, and “passenger” mutations, which, as their name suggests, may not contribute to the progression of a tumor and are unlikely to be useful therapeutic targets. McGranahan et al. identified patterns of driver event evolution in a wide variety of tumor types, revealing specific patterns of mutations that will be important in the design of future therapeutic regimens for cancer.
- Copyright © 2015, American Association for the Advancement of Science
