Research ArticleCancer

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

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Science Translational Medicine  15 Apr 2015:
Vol. 7, Issue 283, pp. 283ra51
DOI: 10.1126/scitranslmed.aaa4442

Article Information

vol. 7 no. 283 283ra51

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 7, 2014
  • Accepted for publication March 18, 2015
  • .

Author Information

  1. Ana Bosch1,*,
  2. Zhiqiang Li1,
  3. Anna Bergamaschi2,
  4. Haley Ellis1,
  5. Eneda Toska1,
  6. Aleix Prat3,4,
  7. Jessica J. Tao5,
  8. Daniel E. Spratt6,
  9. Nerissa T. Viola-Villegas6,,
  10. Pau Castel1,
  11. Gerard Minuesa7,
  12. Natasha Morse1,
  13. Jordi Rodón8,9,
  14. Yasir Ibrahim10,
  15. Javier Cortes8,
  16. Jose Perez-Garcia8,
  17. Patricia Galvan3,
  18. Judit Grueso10,
  19. Marta Guzman10,
  20. John A. Katzenellenbogen11,
  21. Michael Kharas7,
  22. Jason S. Lewis6,7,
  23. Maura Dickler12,
  24. Violeta Serra10,
  25. Neal Rosen7,
  26. Sarat Chandarlapaty1,12,13,,
  27. Maurizio Scaltriti1, and
  28. José Baselga1,12,13,
  1. 1Human Oncology and Pathogenesis Program and Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  2. 2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, Urbana, IL 61801, USA.
  3. 3Translational Genomics Group, Vall d’Hebron Institute of Oncology (VHIO), Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain.
  4. 4Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute, Hospital Clinic Barcelona, C/Rosselló 149-153, Barcelona 08035, Spain.
  5. 5Massachusetts General Hospital Cancer Center and Harvard Medical School, 425 13th Street, Charlestown, MA 02129, USA.
  6. 6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Molecular Pharmacology and Chemistry Program and Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Department of Medical Oncology, VHIO, Barcelona 08035, Spain.
  9. 9Universitat Autònoma de Barcelona, Plaza Cívica, Campus UAB, 08193 Bellaterra, Spain.
  10. 10Experimental Therapeutics Group, VHIO, Barcelona 08035, Spain.
  11. 11Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  12. 12Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  13. 13Weill Cornell Medical College, New York, NY 10065, USA.
  1. Corresponding author. E-mail: chandars{at}mskcc.org (S.C.); scaltrim{at}mskcc.org (M.S.); baselgaj{at}mskcc.org (J.B.)
  • * Present address: Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Medicon Village Building 404:C2, Scheelevägen 2, SE-223 81 Lund, Sweden.

  • Present address: Department of Oncology, Karmanos Cancer Institute, 4100 John R. Street, Detroit, MI 48201, USA.

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