Beyond 3D culture models of cancer

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Science Translational Medicine  15 Apr 2015:
Vol. 7, Issue 283, pp. 283ps9
DOI: 10.1126/scitranslmed.3009367


The mechanisms underlying the spatiotemporal evolution of tumor ecosystems present a challenge in evaluating drug efficacy. In this Perspective, we address the use of three-dimensional in vitro culture models to delineate the dynamic interplay between the tumor and the host microenvironment in an effort to attain realistic platforms for assessing pharmaceutical efficacy in patients.

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