Contents
Vol 7, Issue 283
Contents
Perspective
- Beyond 3D culture models of cancer
Three-dimensional culture models can represent cancer and its microenvironment and provide a platform for pharmaceutical testing.
Research Articles
- PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer
Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer.
- STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Cyclic dinucleotide formulated cancer vaccine combined with PD-1 blockade can induce regression of tumors that do not express PD-L1 constitutively.
- Personalized genomic analyses for cancer mutation discovery and interpretation
Analysis of matched tumor and normal DNA from the same patient improves accuracy of identification of actionable mutations, allowing better targeting of potential treatments.
- Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
Pan-cancer analysis of tumor subclonal structures uncovers widespread intratumor heterogeneity in actionable driver events and reveals mutational processes fueling their selection.
- Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients
Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients.
Review
- The emerging field of mobile health
Mobile technologies can transform clinical research and health care worldwide—and save money.
Editors' Choice
- Of obese mice and monkeys: Protective effects of PI3K inhibition
Inhibiting PI3K signaling in obese mice and rhesus monkeys safely reduced adiposity and metabolic abnormalities.
- Beating BRAF resistance
A sequencing study defines resistance mechanisms to BRAF inhibition in colorectal tumors and reveals a possible Achilles’ heel.
- Shaping up nicely
Sophisticated imaging reveals that the shape of implanted biomaterials determines their ability to support blood vessel growth.
- Singled out: Profiling metabolic and proteomic heterogeneity
A microfluidic assay enables multiplexed single-cell analysis of metabolites and proteins in glioblastoma cells.