15 April 2015
Vol 7, Issue 283
  • Contents

    • Perspective

      • Beyond 3D culture models of cancer

        Three-dimensional culture models can represent cancer and its microenvironment and provide a platform for pharmaceutical testing.

    • Research Articles

      • PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

        Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer.

      • STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

        Cyclic dinucleotide formulated cancer vaccine combined with PD-1 blockade can induce regression of tumors that do not express PD-L1 constitutively.

      • Personalized genomic analyses for cancer mutation discovery and interpretation

        Analysis of matched tumor and normal DNA from the same patient improves accuracy of identification of actionable mutations, allowing better targeting of potential treatments.

      • Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

        Pan-cancer analysis of tumor subclonal structures uncovers widespread intratumor heterogeneity in actionable driver events and reveals mutational processes fueling their selection.

      • Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

        Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients.

    • Review

    • Editors' Choice

      • Beating BRAF resistance

        A sequencing study defines resistance mechanisms to BRAF inhibition in colorectal tumors and reveals a possible Achilles’ heel.

      • Shaping up nicely

        Sophisticated imaging reveals that the shape of implanted biomaterials determines their ability to support blood vessel growth.

About The Cover

Cover image expansion

ONLINE COVER Cancer in the Spotlight. The cover image shows a patient receiving chemotherapy, one of the mainstays of cancer treatment over the past few decades. This week's issue of Science Translational Medicine, coinciding with the annual conference of the American Association for Cancer Research, features research articles on cancer genomics, immunotherapy, and other approaches that are advancing the targeted diagnosis and treatment of cancer, helping to personalize therapy and improve its effectiveness beyond that of standard chemotherapy. [CREDIT: AMELIE-BENOIST/BSIP/CORBIS]