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Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib

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Science Translational Medicine  08 Apr 2015:
Vol. 7, Issue 282, pp. 282ra50
DOI: 10.1126/scitranslmed.3010722

Article Information

vol. 7 no. 282 282ra50

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 22, 2014
  • Accepted for publication February 18, 2015
  • .

Author Information

  1. Christopher Jedeszko1,*,
  2. Marta Paez-Ribes1,*,
  3. Teresa Di Desidero2,*,
  4. Shan Man1,
  5. Christina R. Lee1,
  6. Ping Xu1,
  7. Georg A. Bjarnason3,
  8. Guido Bocci2 and
  9. Robert S. Kerbel1,4,
  1. 1Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
  2. 2Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, University of Pisa, Pisa 56126, Italy.
  3. 3Sunnybrook Odette Cancer Centre, Toronto, Ontario M4N 3M5, Canada.
  4. 4Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
  1. Corresponding author. E-mail: robert.kerbel{at}sri.utoronto.ca
    • * These authors contributed equally to this work.

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