Contents
Vol 7, Issue 282
Contents
Focus
- Spreading depression: Epilepsy’s wave of death
Seizures trigger a wave of depression in brain stem nuclei, leading to cardiorespiratory collapse and sudden death.
Commentary
- Key elements for nourishing the translational research environment
Translation in an academic environment requires a support system—people, goals, models, partnerships, and infrastructures—that will push promising basic science and technology projects forward into the clinic.
Research Articles
- Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models
Ion channel mutations that cause epilepsy also predispose the immature brainstem to generate a depolarizing, tsunami-like wave that leads to autonomic collapse and death.
- Vitamin D–dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma
Vitamin D promotes tumoricidal activity of macrophages and improves the efficacy of antibody-dependent cellular cytotoxicity.
- Long-lasting stem cell–like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination
The yellow fever vaccine induces a CD8+ T stem cell–like memory subset with a naïve-like profile that persists long term.
- Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
Over-the-counter allergy drug chlorcyclizine was identified and characterized as an anti-HCV drug in vitro and in vivo.
- Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib
The combination of metronomic topotecan and pazopanib has potent antitumor effects in models of primary and metastatic renal cancer.
Editors' Choice
- When Langerhans’ and Cajal’s worlds collide, diabetics win
A new antidiabetic therapy has emerged from the demonstration that a neuronal receptor expressed on pancreatic β cells tightly regulates insulin secretion after glucose exposure.
- Metabolic sanctions against epilepsy
Suppression of LDH in astrocytes provides a new therapeutic approach against epilepsy.
- T cell therapy in mice and men
Transgenic mice generate human T cell receptors that recognize cancer cells as foreign.
- Beauty is only skin deep
Human skin represents a complex interaction between our cells, our microbes, our environment, and our beauty products.
