Research ArticlePEDIATRIC CARDIOLOGY

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

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Science Translational Medicine  01 Apr 2015:
Vol. 7, Issue 281, pp. 281ra45
DOI: 10.1126/scitranslmed.aaa5171

Article Information

vol. 7 no. 281 281ra45

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History: 
  • Received for publication December 18, 2014
  • Accepted for publication February 27, 2015
  • .

Author Information

  1. Brian D. Polizzotti1,2,*,
  2. Balakrishnan Ganapathy1,3,*,
  3. Stuart Walsh1,2,*,,
  4. Sangita Choudhury1,2,*,
  5. Niyatie Ammanamanchi1,3,
  6. David G. Bennett4,,
  7. Cristobal G. dos Remedios5,
  8. Bernhard J. Haubner6,
  9. Josef M. Penninger6 and
  10. Bernhard Kühn1,2,3,7,8,9,§
  1. 1Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.
  2. 2Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
  4. 4Preclinical MRI Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  5. 5Department of Anatomy, Bosch Institute, The University of Sydney, Sydney, New South Wales 2006, Australia.
  6. 6Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.
  7. 7Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  8. 8Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  9. 9McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
  1. § Corresponding author. E-mail: bernhard.kuhn2{at}chp.edu
    • * These authors contributed equally to this work.

    • Present address: Bayer Healthcare, 42096 Wuppertal, Germany.

    • Present address: PAREXEL Informatics, Billerica, MA 01821, USA.

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