Contents
Vol 7, Issue 281
Contents
Focus
- Engineering as a new frontier for translational medicine
The inclusion of engineering ideas and approaches makes medicine a quantitative and systems-based discipline that facilitates precision diagnostics and therapeutics improving health care delivery for all.
Perspective
- Developing vaccines for an aging population
The next steps in vaccine development include improving vaccine efficiency and fully leveraging new vaccines.
Research Articles
- G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease
G-SCF–mobilized CD34+ monocytes inhibit graft-versus-host disease by the production of nitric oxide and the induction of regulatory T cells.
- Cytomegalovirus infection enhances the immune response to influenza
Cytomegalovirus infection of young adult humans and mice enhances immune responses to influenza.
- An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth
The cAbl kinase inhibitor imatinib reduces intestinal tumor initiation and growth.
- Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window
The growth factor neuregulin stimulates heart muscle repair in newborn mice and heart muscle from human infants if given during a specific therapeutic time period.
Reports
- Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia
The targeted genotyping of single acute myeloid leukemia cells is technically feasible, identifies the zygosities of concurrent mutations, and suggests that sequencing of bulk populations may underestimate clonal complexity.
Editors' Choice
- A change of heart for phosphodiesterase signaling
PDE9A is a novel myocardial phosphodiesterase that can be pharmacologically inhibited in heart disease.
- Score: N = 1/Tricuspid regurgitation = 0
Compassionate use of a percutaneous mitral valve repair technology to treat tricuspid regurgitation yielded the first human transcatheter tricuspid valve repair.
- Niche guidance of hematopoietic differentiation
The generation of hematopoietic progenitor cells from pluripotent stem cells is enhanced by niche cells and factors.
- Patchwork people: A role for somatic mutations in brain malformations
Somatic mutations in MTOR cause potentially treatable developmental abnormalities of the brain.
- Antibodies complement malaria
Antibodies that recruit complement are important for protection and clearance of malaria parasites, with implications for vaccine development.
