Research ArticleDengue

Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti

See allHide authors and affiliations

Science Translational Medicine  18 Mar 2015:
Vol. 7, Issue 279, pp. 279ra37
DOI: 10.1126/scitranslmed.3010370

Use a bug to fight a bug

Dengue is the most common mosquito-borne viral infection in humans. In this new work, Ferguson et al. have assessed the extent to which infecting mosquitoes with a bacterium called Wolbachia was able to prevent those mosquitoes from being infected with dengue virus after they were fed with blood collected from dengue patients. One Wolbachia strain (wMelPop) almost completely prevented dengue infection. A second strain (wMel) partially blocked dengue infection. A mathematical model fitted to the data collected on the wMel strain suggested that wMel could reduce the transmissibility of dengue by 66 to 75%, enough to eliminate dengue in low or moderate transmission settings.

View Full Text

Stay Connected to Science Translational Medicine