Research ArticleKidney Disease

MG53-mediated cell membrane repair protects against acute kidney injury

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Science Translational Medicine  18 Mar 2015:
Vol. 7, Issue 279, pp. 279ra36
DOI: 10.1126/scitranslmed.3010755

A molecular bandage for kidney injury

MG53 is a protein that is primarily expressed in muscles and helps protect muscle cells from damage. Now, Duann et al. have shown that MG53 performs a similar function in the kidney as well. The authors evaluated the role of MG53 in mouse models of kidney injury induced by ischemia and reperfusion, as well as by cisplatin, a highly nephrotoxic chemotherapy drug. In each case, recombinant MG53 could be given intravenously, and the authors found that it bound to the sites of injury on kidney cells and protected them from further damage and death. MG53 treatment did not interfere with the effectiveness of cisplatin against cancer cells, suggesting that MG53 may be useful for protecting patients’ kidneys during chemotherapy.

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