Contents
Vol 7, Issue 279
Contents
Focus
- Sponsors meet scientists to speed pediatric medicines development
Child-health research initiative enables rapid response to opportunities for participation in multicenter pediatric clinical trials.
- Small RNA: From development to regeneration
A microRNA cluster that targets the Hippo pathway can reintroduce terminally differentiated cardiomyocytes into the cell cycle, promoting heart regeneration (Tian et al., this issue).
Research Articles
- MG53-mediated cell membrane repair protects against acute kidney injury
Recombinant MG53 translocates to sites of injury in the proximal tubule of the kidney and protects mice from acute kidney injury induced by ischemia or drugs.
- Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti
Experimental work and modeling studies reveal that Aedes aegypti infected with the Wolbachia bacterium have reduced vector competence for the transmission of dengue viruses.
- A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation.
- Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells
Four different T cell populations with different functions and migration patterns protect human skin.
- Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Selective inhibition of BCL-XL synergizes with docetaxel to inhibit the growth of solid tumors but does not inhibit granulopoiesis.
- Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAFV600E melanoma
MEK inhibition enhanced the antitumor activity of combined BRAF inhibition and immunotherapy.
Editors' Choice
- The ultimate combination immunotherapy
Combining two checkpoint blockers with radiation yields the best antitumor effects.
- Knocked out: Sleep disturbances after traumatic brain injury
Traumatic brain injury patients have increased sleep need and daytime sleepiness relative to controls.
- You can’t unring a bell
Genetic mouse models of hypertrophic cardiomyopathy suggest that the timing of therapies may be critical for inducing disease regression.
- Fine-tuning inflammasome activity with a small molecule or ketogenic diet
Selective and potent inhibition of NLRP3 inflammasome is a promising therapeutic approach for many complex, metabolic, and inflammatory diseases.
