18 March 2015
Vol 7, Issue 279

About The Cover

Cover image expansion

ONLINE COVER Small RNAs Stimulate Regeneration. The adult heart has limited regenerative capacity. As such, Tian et al. decided to trigger a part of the Hippo signaling pathway that is active during heart development to ensure proper organ size. Increasing miR302-367, a microRNA cluster, in the postnatal adult heart encouraged cardiomyocytes to reenter the cell cycle and proliferate, as noted on the cover by the expression of phopsho-histone H3 (green). (The myocyte protein α-actinin is in red.) Transient treatment with a microRNA mimic decreased scarring and improved heart function after injury in mice, suggesting a viable therapeutic approach to cardiac repair and regeneration. See the related Focus by Martin and colleagues. [CREDIT: Y. TIAN/UNIVERSITY OF PENNSYLVANIA]