11 March 2015
Vol 7, Issue 278

About The Cover

Cover image expansion

ONLINE COVER Bubbles, Beams, and Microglial Activation. Transient opening of the blood-brain barrier results in activation of microglial cells (yellow), which then start engulfing amyloid plaques (gray) in a mouse model of Alzheimer's disease (Leinenga and Götz). Transient opening of the tight junctions of endothelial cells (red) that comprise the blood-brain barrier was induced by injected microbubbles and an ultrasound beam. [CREDIT: CONCEPT NICK VALMAS, THE UNIVERSITY OF QUEENSLAND/ILLUSTRATION BY V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]