Contents
Vol 7, Issue 277
Contents
Editorial
- Moving medicine forward faster
Participants at the recent Translate! 2014 meeting in Berlin, Germany, discussed initiatives to bridge gaps in the biomedical translation process.
Focus
- Make the bleeding stop
A new synthetic polymer that cross-links fibrin shows promise in the management of hemorrhage (Chan et al., this issue).
Research Articles
- Liver-directed lentiviral gene therapy in a dog model of hemophilia B
Gene therapy with lentiviral vectors targeting transgene expression to hepatocytes provides stable reconstitution of clotting activity in dogs with hemophilia B and does not show genotoxicity in tumor-prone mice.
- A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis
By cross-linking fibrin, intravenously injected factor XIII–inspired hemostatic polymers stabilize clots and reduce bleeding in a rat model of trauma and fluid resuscitation.
- Immunological mechanisms of the antitumor effects of supplemental oxygenation
Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.
- Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
GRK2 inhibition with paroxetine improves cardiac function independent of its central nervous system effects.
Editors' Choice
- System-level prescriptions for adaptive drug licensing
A multistakeholder position paper presents a vision of the future for therapeutic translation.
- Tissue engineering the origins of life
Tissue-engineered ovaries may one day restore fertility in survivors of childhood cancer.
- Boosting our brains
A human-specific enhancer of the FZD8 gene increases size and neuronal density of the brain.
Erratum
