Contents
Vol 7, Issue 276
Contents
Focus
- Tuberculosis vaccines: Time for a global strategy
We need a global strategy for the development of better tuberculosis vaccines.
- Paying for innovation: Reimbursement incentives for antibiotics
Reimbursement incentives could promote antibiotic research and development—in particular, for new drugs to treat complex infections commonly found in hospitals.
Perspective
- Financing translation: Analysis of the NCATS rare-diseases portfolio
Simulations using National Center for Advancing Translational Sciences data show that a portfolio of rare-disease therapeutics can yield attractive financial returns.
Research Articles
- Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
Gut bacterial strains targeted by IgA in undernourished Malawian children produce severe enteropathy in gnotobiotic mice and correlate with health status.
- Timely and spatially regulated maturation of B and T cell repertoire during human fetal development
Immunocompetence in the developing fetus is temporally and spatially regulated.
- Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease
Intracisternal injection of cyclodextrin into cats with Niemann-Pick type C1 disease results in Purkinje cell survival and normal neurological function, suggesting its usefulness for treating the human disease.
- Oxidation increases mucin polymer cross-links to stiffen airway mucus gels
A thiol-modified carbohydrate compound treats pathologic mucus gel formation in inflamed airways.
Editors' Choice
- Autism heritability: A new twist on familial genetics?
Analysis of whole-genome sequencing data suggests that a substantial proportion of presumed pathogenic mutations are not shared by autistic siblings.
- Neurons cool off
The cold shock–induced protein RBM3 controls synapse regeneration and protects mice with neurodegenerative disease.
- Nanocarriers deliver DNA to brain tumors
Nanoparticles can deliver suicide gene therapy to CNS tumors.
- Seq and the city
City-scale metagenomics reveal who we are and the dynamic environment we live in.
