Research ArticleImmunotherapy

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

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Science Translational Medicine  18 Feb 2015:
Vol. 7, Issue 275, pp. 275ra22
DOI: 10.1126/scitranslmed.aaa4963

Article Information

vol. 7 no. 275 275ra22

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 12, 2014
  • Accepted for publication January 23, 2015
  • .

Author Information

  1. Laura A. Johnson1,2,*,
  2. John Scholler1,*,
  3. Takayuki Ohkuri3,
  4. Akemi Kosaka3,
  5. Prachi R. Patel1,
  6. Shannon E. McGettigan1,
  7. Arben K. Nace4,
  8. Tzvete Dentchev4,
  9. Pramod Thekkat5,
  10. Andreas Loew5,
  11. Alina C. Boesteanu1,
  12. Alexandria P. Cogdill1,
  13. Taylor Chen1,
  14. Joseph A. Fraietta1,
  15. Christopher C. Kloss1,
  16. Avery D. Posey Jr.1,
  17. Boris Engels5,
  18. Reshma Singh5,
  19. Tucker Ezell5,
  20. Neeraja Idamakanti5,
  21. Melissa H. Ramones5,
  22. Na Li5,
  23. Li Zhou5,
  24. Gabriela Plesa1,
  25. John T. Seykora4,
  26. Hideho Okada6,
  27. Carl H. June1,2,
  28. Jennifer L. Brogdon5 and
  29. Marcela V. Maus1,7,
  1. 1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  4. 4Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  6. 6Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  7. 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. Corresponding author. E-mail: marcela.maus{at}uphs.upenn.edu
    • * These authors contributed equally to this work.

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