18 February 2015
Vol 7, Issue 275

About The Cover

Cover image expansion

ONLINE COVER Resolving Inflammation. There are many lipid-lowering therapies and drugs for the acute inflammation associated with atherosclerosis, but resolving chronic inflammation may be a better tactic for treating advanced disease. In this issue, Fredman et al. engineered plaque-targeted nanoparticles carrying a proresolving peptide derived from annexin A1 (on cover). In rodent models of advanced atherosclerosis, the nanomedicine stabilized plaques at risk of rupture by acting on macrophages and other components of the chronic inflammatory response. See the related Focus by Soehnlein that emphasizes this shift in therapeutic mentality for atherosclerosis, from anti-inflammatory to proresolving. [CREDIT: H. McDONALD/SCIENCE TRANSLATIONAL MEDICINE]