Intraoperative brain cancer detection with Raman spectroscopy in humans

Michael Jermyn; Kelvin Mok; Jeanne Mercier; Joannie Desroches; Julien Pichette; Karl Saint-Arnaud; Liane Bernstein; Marie-Christine Guiot; Kevin Petrecca; Frederic Leblond

doi:10.1126/scitranslmed.aaa2384

Research ArticleCancer Imaging

Intraoperative brain cancer detection with Raman spectroscopy in humans

Michael Jermyn¹,²,*,
Kelvin Mok³,*,
Jeanne Mercier²,
Joannie Desroches⁴,
Julien Pichette²,
Karl Saint-Arnaud²,
Liane Bernstein²,
Marie-Christine Guiot¹,⁵,
Kevin Petrecca¹,†,‡ and
Frederic Leblond²,†,‡

¹Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
²Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.
³Neuronavigation Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
⁴Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
⁵Division of Neuropathology, Department of Pathology, McGill University, Montreal, Quebec H3A 2B4, Canada.

↵‡Corresponding author. E-mail: kevin.petrecca{at}mcgill.ca (K.P.); leblondfrederic{at}gmail.com (F.L.)

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work.

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Science Translational Medicine 11 Feb 2015:
Vol. 7, Issue 274, pp. 274ra19
DOI: 10.1126/scitranslmed.aaa2384

Michael Jermyn

1Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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Kelvin Mok

3Neuronavigation Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.

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Jeanne Mercier

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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Joannie Desroches

4Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

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Julien Pichette

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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Karl Saint-Arnaud

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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Liane Bernstein

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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Marie-Christine Guiot

1Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

5Division of Neuropathology, Department of Pathology, McGill University, Montreal, Quebec H3A 2B4, Canada.

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Kevin Petrecca

1Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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For correspondence: kevin.petrecca@mcgill.ca leblondfrederic@gmail.com

Frederic Leblond

2Department of Engineering Physics, Polytechnique Montréal, CP 6079, Succursale Centre-Ville, Montreal, Quebec H3C 3A7, Canada.

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For correspondence: kevin.petrecca@mcgill.ca leblondfrederic@gmail.com

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Intraoperative brain cancer detection with Raman spectroscopy in humans

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