Contents
Vol 7, Issue 274
Contents
Focus
- Targeting metabolism for lupus therapy
Drugs that correct defects in T cell metabolism may prove to be promising treatments for lupus.
- fMRI in analgesic drug discovery
Functional magnetic resonance imaging offers an unprecedented opportunity to evaluate and compare drug effects on human brain activity and to provide a systems-level prediction of how drugs for chronic pain affect the brain, thus accelerating drug discovery and repurposing.
Research Articles
- Learning to identify CNS drug action and efficacy using multistudy fMRI data
Existing functional brain imaging data sets were used to identify neural signatures that confirm pharmacological action and predict clinical efficacy of test compounds.
- Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Glutamine-based PET imaging takes advantage of gliomas’ glutamine addiction and can be used to assess metabolic nutrient uptake in gliomas.
- Normalization of CD4+ T cell metabolism reverses lupus
Systemic lupus erythematosus is associated with enhanced CD4+ T cell metabolism and can be reversed by metabolic modulators.
- Intraoperative brain cancer detection with Raman spectroscopy in humans
A handheld Raman spectroscopy probe enabled detection of invasive brain cancer intraoperatively in patients with grade 2 to 4 gliomas.
Editors' Choice
- A molecular patch for DMD
Antisense oligonucleotides rescue symptoms of Duchenne muscular dystrophy.
- Looking at the 99% in nature to stop drug-resistant bacteria
New antibiotics without detectable resistance were discovered in unculturable soil bacteria.
- Predicting the road not taken
A gene signature from the macrophages in a chronic wound reveals whether the ulcer is destined to heal.
- Neuroinflammation: Friend or foe?
The anti-inflammatory cytokine IL-10 unexpectedly worsens pathology in mouse models of Alzheimer’s disease by impairing the normal immune response to amyloid-β.
Erratum
