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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

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Science Translational Medicine  04 Feb 2015:
Vol. 7, Issue 273, pp. 273ra15
DOI: 10.1126/scitranslmed.aaa3634

Article Information

vol. 7 no. 273 273ra15

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 24, 2014
  • Accepted for publication January 16, 2015
  • .

Author Information

  1. Reina N. Fuji1,*,
  2. Michael Flagella1,
  3. Miriam Baca2,
  4. Marco A. S. Baptista3,
  5. Jens Brodbeck1,
  6. Bryan K. Chan4,
  7. Brian K. Fiske3,
  8. Lee Honigberg5,
  9. Adrian M. Jubb2,
  10. Paula Katavolos1,
  11. Donna W. Lee1,
  12. Sock-Cheng Lewin-Koh6,
  13. Tori Lin1,
  14. Xingrong Liu7,
  15. Shannon Liu1,
  16. Joseph P. Lyssikatos4,
  17. Jennifer O’Mahony1,
  18. Mike Reichelt2,
  19. Merone Roose-Girma8,
  20. Zejuan Sheng9,
  21. Todd Sherer3,
  22. Ashley Smith5,
  23. Margaret Solon2,
  24. Zachary K. Sweeney4,
  25. Jacqueline Tarrant1,
  26. Alison Urkowitz3,
  27. Søren Warming8,
  28. Murat Yaylaoglu2,
  29. Shuo Zhang9,
  30. Haitao Zhu9,
  31. Anthony A. Estrada4 and
  32. Ryan J. Watts9,*
  1. 1Department of Safety Assessment, Genentech Inc., South San Francisco, CA 94080, USA.
  2. 2Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
  3. 3The Michael J. Fox Foundation for Parkinson’s Research, New York, NY 10018, USA.
  4. 4Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Department of Pharmacodynamic Biomarkers, Genentech Inc., South San Francisco, CA 94080, USA.
  6. 6Department of Nonclinical Biostatistics, Genentech Inc., South San Francisco, CA 94080, USA.
  7. 7Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.
  8. 8Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.
  9. 9Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  1. *Corresponding author. E-mail: fuji.reina{at}gene.com (R.N.F.); watts.ryan{at}gene.com (R.J.W.)

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