04 February 2015
Vol 7, Issue 273
  • Contents

    • Perspective

    • Research Articles

      • In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

        Genetically engineered T memory stem cells preserve differentiation activity for decades after patient infusion.

      • Local iontophoretic administration of cytotoxic therapies to solid tumors

        Local administration of cytotoxic drugs using iontophoresis results in drug accumulation and therapeutic efficacy in mouse models of pancreatic and breast cancer and favorable PK in a large animal model.

      • Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

        LRRK2 kinase inhibitors, under development for Parkinson’s disease, have an effect on type II pneumocytes in nonhuman primate lung, suggesting that pulmonary toxicity may be a critical safety liability.

    • Reports

      • A smartphone dongle for diagnosis of infectious diseases at the point of care

        A smartphone accessory can perform a point-of-care test that simultaneously detects three infectious disease markers from fingerprick whole blood in 15 min, as operated by health care workers trained on a software app.

    • Editors' Choice

      • T cells in a (polymer) matrix

        Placing tumor-specific T cells in a polymer scaffold enhances their efficacy in solid tumors.

      • Leaky blood-brain barriers and memory loss

        Age-dependent blood-brain barrier permeability demonstrated an association with cognitive impairment.

About The Cover

Cover image expansion

ONLINE COVER Tracking T Cells. Electronic tags have proven a paradigm shift in ecologists' ability to track and understand migrating animals, such as the sea turtle shown. Now, Biasco et al. use this same idea to track T cells long term in human patients. The authors used genetic modifications from T cells used in a gene therapy study as tags to explore the in vivo function of human memory stem T cells. They found these cells remained functional and survived for at least a decade, supporting their use in targeted immunotherapies. [CREDIT: GETTY IMAGES/NATIONAL GEOGRAPHIC CREATIVE]