Contents
Vol 7, Issue 273
Contents
Perspective
- Cellular stress drives pancreatic plasticity
Physiological and nonphysiological stress induces intrapancreatic cell-to-cell conversion.
Research Articles
- In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
Genetically engineered T memory stem cells preserve differentiation activity for decades after patient infusion.
- Local iontophoretic administration of cytotoxic therapies to solid tumors
Local administration of cytotoxic drugs using iontophoresis results in drug accumulation and therapeutic efficacy in mouse models of pancreatic and breast cancer and favorable PK in a large animal model.
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
LRRK2 kinase inhibitors, under development for Parkinson’s disease, have an effect on type II pneumocytes in nonhuman primate lung, suggesting that pulmonary toxicity may be a critical safety liability.
Reports
- A smartphone dongle for diagnosis of infectious diseases at the point of care
A smartphone accessory can perform a point-of-care test that simultaneously detects three infectious disease markers from fingerprick whole blood in 15 min, as operated by health care workers trained on a software app.
Editors' Choice
- The many faces of hepatocellular carcinoma
Hepatocellular carcinoma has substantial heterogeneity at the cell, marker, and genetic level.
- T cells in a (polymer) matrix
Placing tumor-specific T cells in a polymer scaffold enhances their efficacy in solid tumors.
- Leaky blood-brain barriers and memory loss
Age-dependent blood-brain barrier permeability demonstrated an association with cognitive impairment.
- Beam me up, Scotty: The future of ablation
Noninvasive ablation of arrhythmias could become a reality with ion beam technology.
