Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

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Science Translational Medicine  21 Jan 2015:
Vol. 7, Issue 271, pp. 271ra9
DOI: 10.1126/scitranslmed.3010626

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Fewer Lesions, More Little Mice

Endometriosis is a poorly understood disorder of the female reproductive system, where collections of tissue that normally lines the uterus appear outside the uterus as well. These tissue deposits can be found anywhere in the abdominal cavity, where they cause inflammation and pain, and often also decreased fertility. Although some hormonal treatments for endometriosis exist, they are not always effective, have numerous side effects, and also suppress fertility. Now, Zhao et al. present some mechanistic explanations for the inflammatory phenomena seen in endometriosis. Even more importantly, the authors identified two new estrogen receptor ligands that can suppress endometriosis in mouse models safely and effectively, without disrupting the animals’ reproductive cycles and fertility.

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