21 January 2015
Vol 7, Issue 271
  • Contents

    • Focus

    • Perspective

      • Cancer and the gut microbiota: An unexpected link

        Gut microbiota and its interactions with the host immune system play a role in oncogenesis and can alter the effectiveness of anticancer agents.

    • Research Articles

    • Editors' Choice

      • Micro(exon)-management

        Alternative splicing of small DNA fragments contributes to neuronal development and may be linked to certain neurodevelopmental disorders.

      • Control under pressure

        A new transdermal drug-delivery system treats and prevents diabetic pressure ulcers.

      • Stem cell transplants may HALT multiple sclerosis

        High-dose immunosuppressive therapy combined with autologous hematopoietic cell transplantation results in 3-year sustained remission in multiple sclerosis patients.

About The Cover

Cover image expansion

ONLINE COVER Seeing Nanostars. Microscopic tumors may be invisible to the naked eye, but they are no match for nanosized imaging agents, which penetrate cancer tissue to signal the presence of disease. Harmsen et al. created a new generation of cancer imaging agents, called "nanostars"—a star-shaped gold core and a Raman reporter molecule wrapped in silica—that can be visualized by surface-enhanced resonance Raman scattering, or SERRS. The nanostars were used to image micro- and macroscopic premalignant and cancerous lesions in animal models of cancer, including pancreatic, breast, prostate, and sarcoma. As handheld Raman imaging devices are further developed, SERRS nanostars are sure to find a place in the clinic. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]