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The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge

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Science Translational Medicine  14 Jan 2015:
Vol. 7, Issue 270, pp. 270ra5
DOI: 10.1126/scitranslmed.3010297

A Step-Up for PrEP

Daily preexposure prophylaxis (PrEP) is effective in preventing HIV acquisition among men and women, but many are not able to adhere to the daily pill schedule and cannot fully benefit from PrEP. New long-acting antiretroviral formulations provide sustained drug delivery for many weeks and do not require adherence between medication visits. Here, Radzio et al. showed in macaques that the long-acting integrase inhibitor GSK744, at concentrations achievable in humans by quarterly injections, afforded protection against repeated vaginal simian HIV challenges. These findings support the clinical development of GSK744 LA as a PrEP agent for HIV prevention in women.