14 January 2015
Vol 7, Issue 270
  • Contents

    • Focus

    • Research Articles

    • Editors' Choice

      • Lymph Nodes “On Demand”

        Injected microparticles spontaneously form three-dimensional structures that can mobilize anticancer immune responses.

      • Fear as a Cardiovascular Risk Factor

        Fear is one of the factors associated with a paradoxical rise in heart rate during aging.

About The Cover

Cover image expansion

ONLINE COVER A Tiny Bit of Titin. An inactive kinase—one of 244 domains in this giant protein—from the carboxyl-terminal region of titin, a mammoth muscle protein thought to be the largest in existence. Integral to muscle structure and function, titin helps give muscle its elasticity Roberts et al. show that when titin's carboxyl-terminal region harbors a mutation, it often causes serious heart disease. Mutations at the other, amino-terminal end of titin tend to be innocuous and are found in many perfectly healthy people. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]