Research ArticleImmunology

mTOR inhibition improves immune function in the elderly

See allHide authors and affiliations

Science Translational Medicine  24 Dec 2014:
Vol. 6, Issue 268, pp. 268ra179
DOI: 10.1126/scitranslmed.3009892

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

mTOR and Human Aging

Inhibition of mTOR signaling extends life span and delays the onset of aging-related diseases in all species studied to date. These findings suggest that the mTOR pathway regulates aging. However, it is unknown if mTOR inhibition has beneficial effects on aging in humans. To begin to address this question, Mannick et al. evaluated the effects of the mTOR inhibitor RAD001 on the decline in immune function that occurs during aging in humans. Their findings suggest that RAD001 improved immune function in elderly volunteers as assessed by response to influenza vaccination. It remains to be determined whether mTOR inhibition improves additional aging-related conditions in humans.

View Full Text

Stay Connected to Science Translational Medicine

Editor's Blog