Research ArticleHuntington’s Disease

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease

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Science Translational Medicine  24 Dec 2014:
Vol. 6, Issue 268, pp. 268ra178
DOI: 10.1126/scitranslmed.3010523

Article Information

vol. 6 no. 268 268ra178

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 29, 2014
  • Accepted for publication November 26, 2014
  • .

Author Information

  1. Xiao-Hong Lu1,2,3,
  2. Virginia B. Mattis4,
  3. Nan Wang1,2,3,
  4. Ismael Al-Ramahi5,6,
  5. Nick van den Berg7,
  6. Silvina A. Fratantoni7,
  7. Henry Waldvogel8,
  8. Erin Greiner1,2,3,
  9. Alex Osmand9,
  10. Karla Elzein5,6,
  11. Jingbo Xiao10,
  12. Sipke Dijkstra7,
  13. Remko de Pril11,
  14. Harry V. Vinters12,
  15. Richard Faull8,
  16. Ethan Signer13,
  17. Seung Kwak13,
  18. Juan J. Marugan10,
  19. Juan Botas5,6,
  20. David F. Fischer7,
  21. Clive N. Svendsen4,
  22. Ignacio Munoz-Sanjuan13 and
  23. X. William Yang1,2,3,*
  1. 1Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
  2. 2Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  3. 3UCLA Brain Research Institute, Los Angeles, CA 90095, USA.
  4. 4Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  5. 5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  6. 6Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA.
  7. 7BioFocus, a Charles River company, Leiden 233CR, the Netherlands.
  8. 8Department of Anatomy with Radiology, Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.
  9. 9Department of Biochemistry and Cellular and Molecular Biology, Knoxville, TN 37996, USA.
  10. 10NIH Chemical Genomic Center, National Center for Advancing Translation Sciences, National Institutes of Health, Rockville, MD 20892, USA.
  11. 11Galapagos, Leiden, the Netherlands.
  12. 12Department of Pathology and Laboratory Medicine (Neurology), David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  13. 13CHDI Foundation/CHDI Management Inc., Los Angeles, CA 90045, USA.
  1. *Corresponding author. E-mail: xwyang{at}mednet.ucla.edu

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