Research ArticleCancer

Recurrent epimutation of SDHC in gastrointestinal stromal tumors

See allHide authors and affiliations

Science Translational Medicine  24 Dec 2014:
Vol. 6, Issue 268, pp. 268ra177
DOI: 10.1126/scitranslmed.3009961

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

All Roads Lead to Loss of Expression

Gastrointestinal stromal tumors are the most common mesenchymal tumors in the gastrointestinal tract, and they can occur in isolation or as part of a constellation of cancers known as Carney triad. A subtype of this cancer, characterized by lack of expression in a gene called SDH, is not well understood and lacks a specific treatment, and this is the type that most commonly occurs in children. Now, Killian et al. have identified methylation of the SDH gene in patients with SDH-deficient gastrointestinal stromal tumors who lack mutations in the SDH gene. This finding provides a common link explaining the pathogenesis of these SDH-deficient tumors, including many of the ones associated with Carney triad.

View Full Text