Contents
Vol 6, Issue 268
Contents
Research Articles
- Recurrent epimutation of SDHC in gastrointestinal stromal tumors
Methylation of the SDH gene explains the loss of SDH gene expression in SDH wild-type gastrointestinal stromal tumors.
- Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease
Reducing ATM signaling is neuroprotective in cell and animal models of Huntington’s disease.
- mTOR inhibition improves immune function in the elderly
mTOR inhibition by RAD001 improves immune responses in elderly volunteers receiving an influenza vaccination.
Editors' Choice
- Ctrl-Alt-Del: Host-Targeting Anti-Angiogenic Agents as Adjunct Therapy for Tuberculosis
Inhibition of granuloma-associated angiogenesis reduces mycobacterial burden and dissemination.
- Muscles Protect the Kidneys
Skeletal muscles halt the progression of kidney failure through the kinase Akt1.
- Protein Clearance Ain’t What It Used to Be
A glial system for flushing waste proteins from the brain declines with age, revealing a possible mechanistic link between aging and protein aggregation.
Letters
- Reply to comment on “An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice”
Possible reasons for why a new study could not replicate our finding that the serotonin reuptake inhibitor citalopram decreased amyloid β concentrations in the cerebrospinal fluid of healthy volunteers.
- Comment on “An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice”
A study attempts to replicate the finding that the serotonin reuptake inhibitor citalopram decreases amyloid β concentrations in the cerebrospinal fluid of healthy volunteers.
