17 December 2014
Vol 6, Issue 267

About The Cover

Cover image expansion

ONLINE COVER Holographic Pathology. Giving pathologists a better view, Greenbaum and colleagues have created a lens-free holographic microscope that delivers high-resolution images of human tissue samples (artistically rendered in pink), with a field of view 100-fold greater than conventional lens-based light microscopes. The microscope—based on an image sensor chip (in blue)—can also automatically focus the images in 3D and, with the aid of computational methods, color the images, similar to what is seen after traditional tissue staining. The authors used the new device to image large areas of human breast cancer tissues, abnormal Pap smears, and blood smears from patients with sickle cell disease. Lens-free imaging may be a cost-effective alternative to traditional microscopy, especially in resource-limited settings. [CREDIT: Y. ZHANG/UNIVERSITY OF CALIFORNIA, LOS ANGELES]