Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

James M. Hill; Debra C. Quenelle; Rhonda D. Cardin; Jodi L. Vogel; Christian Clement; Fernando J. Bravo; Timothy P. Foster; Marta Bosch-Marce; Priya Raja; Jennifer S. Lee; David I. Bernstein; Philip R. Krause; David M. Knipe; Thomas M. Kristie

doi:10.1126/scitranslmed.3010643

Research ArticleHerpes Simplex Virus

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

James M. Hill¹,*,
Debra C. Quenelle²,
Rhonda D. Cardin³,
Jodi L. Vogel⁴,
Christian Clement¹,†,
Fernando J. Bravo³,
Timothy P. Foster¹,
Marta Bosch-Marce⁵,
Priya Raja⁶,
Jennifer S. Lee⁶,⁷,
David I. Bernstein³,
Philip R. Krause⁵,
David M. Knipe⁶,⁷ and
Thomas M. Kristie⁴,‡

¹Department of Ophthalmology and Department of Microbiology, Immunology, and Parasitology, LSU Eye Center, Louisiana State University Health Science Center School of Medicine, New Orleans, LA 70112, USA.
²Department of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
³Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
⁴National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁵Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.
⁶Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.
⁷Harvard Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

↵‡Corresponding author. E-mail: tkristie{at}niaid.nih.gov

↵* It is with sadness and respect that we mark the passing of our colleague J.M.H.
† Present address: Department of Natural Sciences, Southern University at New Orleans, New Orleans, LA 70126, USA.

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Science Translational Medicine 03 Dec 2014:
Vol. 6, Issue 265, pp. 265ra169
DOI: 10.1126/scitranslmed.3010643

James M. Hill

1Department of Ophthalmology and Department of Microbiology, Immunology, and Parasitology, LSU Eye Center, Louisiana State University Health Science Center School of Medicine, New Orleans, LA 70112, USA.

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Debra C. Quenelle

2Department of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Rhonda D. Cardin

3Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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Jodi L. Vogel

4National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Christian Clement

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Fernando J. Bravo

3Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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Timothy P. Foster

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Marta Bosch-Marce

5Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.

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Priya Raja

6Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.

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Jennifer S. Lee

6Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.

7Harvard Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

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David I. Bernstein

3Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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Philip R. Krause

5Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.

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David M. Knipe

6Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.

7Harvard Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

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Thomas M. Kristie

4National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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For correspondence: tkristie@niaid.nih.gov

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Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

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