Contents

Contents

• Research Articles

  • PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis

    By Ray Y. Chen, Lori E. Dodd, Myungsun Lee, Praveen Paripati, Dima A. Hammoud, James M. Mountz, Doosoo Jeon, Nadeem Zia, Homeira Zahiri, M. Teresa Coleman, Matthew W. Carroll, Jong Doo Lee, Yeon Joo Jeong, Peter Herscovitch, Saher Lahouar, Michael Tartakovsky, Alexander Rosenthal, Sandeep Somaiyya, Soyoung Lee, Lisa C. Goldfeder, Ying Cai, Laura E. Via, Seung-Kyu Park, Sang-Nae Cho, Clifton E. Barry III

    Science Translational Medicine03 Dec 2014 : 265ra166 Full AccessRestricted Access

    PET/CT imaging in humans with TB correlates with drug response and final treatment outcomes.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis

    By M. Teresa Coleman, Ray Y. Chen, Myungsun Lee, Philana Ling Lin, Lori E. Dodd, Pauline Maiello, Laura E. Via, Youngran Kim, Gwendolyn Marriner, Veronique Dartois, Charles Scanga, Christopher Janssen, Jing Wang, Edwin Klein, Sang Nae Cho, Clifton E. Barry III, JoAnne L. Flynn

    Science Translational Medicine03 Dec 2014 : 265ra167 Full AccessRestricted Access

    PET/CT imaging in macaques and humans with TB shows a beneficial therapeutic response to linezolid and a new oxazolidinone antibiotic, AZD5847.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders

    By Sarah E. Soden, Carol J. Saunders, Laurel K. Willig, Emily G. Farrow, Laurie D. Smith, Josh E. Petrikin, Jean-Baptiste LePichon, Neil A. Miller, Isabelle Thiffault, Darrell L. Dinwiddie, Greyson Twist, Aaron Noll, Bryce A. Heese, Lee Zellmer, Andrea M. Atherton, Ahmed T. Abdelmoity, Nicole Safina, Sarah S. Nyp, Britton Zuccarelli, Ingrid A. Larson, Ann Modrcin, Suzanne Herd, Mitchell Creed, Zhaohui Ye, Xuan Yuan, Robert A. Brodsky, Stephen F. Kingsmore

    Science Translational Medicine03 Dec 2014 : 265ra168 Full AccessRestricted Access

    Molecular diagnosis of pediatric neurodevelopmental disorders by genomic sequencing is frequently informative and cost-effective and can affect clinical care.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

    By James M. Hill, Debra C. Quenelle, Rhonda D. Cardin, Jodi L. Vogel, Christian Clement, Fernando J. Bravo, Timothy P. Foster, Marta Bosch-Marce, Priya Raja, Jennifer S. Lee, David I. Bernstein, Philip R. Krause, David M. Knipe, Thomas M. Kristie

    Science Translational Medicine03 Dec 2014 : 265ra169 Full AccessRestricted Access

    Epigenetic suppression of herpes simplex virus demonstrates an approach to control persistent viruses.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• State of the Art Review

  • Wound repair and regeneration: Mechanisms, signaling, and translation

    By Sabine A. Eming, Paul Martin, Marjana Tomic-Canic

    Science Translational Medicine03 Dec 2014 : 265sr6 Full AccessRestricted Access

    The combination of an advanced scientific understanding of tissue repair and regeneration and the identification of knowledge gaps and the limitations of past clinical trials will provide a strong basis to advance viable clinical approaches for treating patients with wound-healing pathologies.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Watch Your Leftovers: Remnant Cholesterol Brings Oversized Risk to Cardiovascular Health

    By Chester L. Drum

    Science Translational Medicine03 Dec 2014 : 265ec205 Full AccessRestricted Access

    A large-scale analysis of a Copenhagen cohort reveals mediators of cardiovascular risk for obese individuals.

    • Full Text

  • The Clot Thickens…

    By Kara L. Spiller

    Science Translational Medicine03 Dec 2014 : 265ec206 Full AccessRestricted Access

    Ultra-deformable synthetic platelets stop bleeding in minutes.

    • Full Text

  • Filled with Evil: Molecular Signatures of Tumor-Associated Immune Cells

    By Jie Sun

    Science Translational Medicine03 Dec 2014 : 265ec207 Full AccessRestricted Access

    Molecular profiling unveils how monocytes and macrophages in human renal cancers contribute to tumor progression.

    • Full Text

  • Morphing Cell Identity to Treat Diabetes

    By Paul J. Tesar

    Science Translational Medicine03 Dec 2014 : 265ec208 Full AccessRestricted Access

    An optimized protocol enables in vivo conversion of pancreatic acinar cells to functional pancreatic beta cells with implications for treating diabetes.

    • Full Text