Contents
Vol 6, Issue 264
Contents
Commentary
- Changing the Mindset in Life Sciences Toward Translation: A Consensus
Participants at the recent Translate! 2014 meeting in Berlin, Germany, reached a consensus on the rate-limiting factor for advancing translational medicine.
Research Articles
- DNA vaccine–derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome
Human polyclonal antibodies generated from DNA-vaccinated, transchromosomal bovines protect against hantavirus pulmonary syndrome.
- Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa
Patient-specific iPSCs were derived, corrected, and differentiated into human skin grafts for the treatment of recessive dystrophic epidermolysis bullosa.
- Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa
Epidermolysis bullosa patient–specific iPSCs were generated from spontaneously corrected revertant keratinocytes for skin reconstitution.
- Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa
iPSCs derived from fibroblasts with mutant type VII collagen were genetically corrected and used as cell therapy in mice with recessive dystrophic epidermolysis bullosa.
Editors' Choice
- Memories on the Clock: A Frequent Flyer’s Nightmare
Disrupting circadian rhythms without altering the neural circuits that make up the “clock” itself impairs recognition and spatial memory.
- Tunneling Through Cell Walls
Carbon nanotubes spontaneously insert into the membranes of living cells to form tiny pores that transport DNA, water, and ions in a controlled manner.
- Crowdsourcing Disease Prognosis
Opening clinical trial data to crowdsourcing improves prognosis in ALS.
