Research ArticleCancer

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

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Science Translational Medicine  19 Nov 2014:
Vol. 6, Issue 263, pp. 263ra161
DOI: 10.1126/scitranslmed.3010382

Article Information

vol. 6 no. 263 263ra161

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 18, 2014
  • Accepted for publication October 9, 2014
  • .

Author Information

  1. Yifeng Xia1,
  2. Yi-Liang Liu2,
  3. Yonghua Xie3,
  4. Wei Zhu2,
  5. Francisco Guerra2,
  6. Shen Shen1,
  7. Narayana Yeddula1,
  8. Wolfgang Fischer4,
  9. William Low4,
  10. Xiaoying Zhou3,
  11. Yonghui Zhang3,5,6,*,
  12. Eric Oldfield2,7,* and
  13. Inder M. Verma1,*
  1. 1Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  2. 2Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  3. 3Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
  4. 4Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  5. 5Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, P.R. China.
  6. 6Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China.
  7. 7Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  1. *Corresponding author. E-mail: verma{at}salk.edu (I.M.V.); eoldfiel{at}illinois.edu (E.O.); zhangyonghui{at}tsinghua.edu.cn (Y.Z.)

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